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16-Mar-2026
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Arch Hellen Med, 43(3), May-June 2026, 348-355 ORIGINAL PAPER Circadian rhythmicity at acute myocardial infraction patients hospitalized in the emergency department E. Delimanoli,1 I. Iliopoulou,1 N. Fotos,1 T. Katsoulas,1 A. Korompeli1,2 |
OBJECTIVE To investigate the influence of circadian rhythmicity during acute myocardial infarction (AMI) (STEMI, nSTEMI).
METHOD A retrospective study of 50 patients who presented to the emergency department of a private clinic in the Athens area in 2021 with symptoms of chest pain. Patients were diagnosed with one of two types of AMI, mornaccording to troponin, CKMB, CPK values and electrocardiogram (ECG) imaging.
RESULTS The sample consisted of 43 men (86%) and 7 women (14%). Regarding the time of onset of symptoms, 60% of patients (n=30) felt heart pain between 06:00–11:59, 16% (n=8) between 12:00–17:59, 22% (n=11) between 18:00–23:59 and 2% (n=1) between 00:00–05:59. The mean time from the onset of AMI symptoms to arrival at the emergency department (ED) was 5.5 hours (mean value=5.51). The values of aPTT, HS Trop and INR were increased in patients with STEMI-type, compared to patients with nSTEMI-type ΑΜΙ (p<0.05). Systolic blood pressure (SBP) (p=0.008) and diastolic blood pressure (DBP) (p=0.009) were increased, while temperature tended to be lower (p=0.093) in patients with STEMI-type, compared to patients with nSTEMI-type ΑΜΙ.
CONCLUSIONS AMI shows periodicity in the time of onset of symptoms. Biomarkers and vital signs show differences according to the type of AMI (STEMI, nSTEMI), while the medical history of the patients is important in terms of the time of arrival of the patients in the EDs.
Key words: Acute myocardial infarction, Circadian rhythms, Emergency department, nSTEMI, STEMI.
