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24-Apr-2007
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Arch Hellen Med, 23(6), November-December 2006, 595-599 ORIGINAL PAPER Drug rashes in HIV patients K.P. KYRIAKIS, V.A. PAPARIZOS, S. KOURKOUNTI, K. LEUWO, C. BOTSI, A. KATSAMBAS |
OBJECTIVE The multiple therapeutic means used in HIV infection induce side effects with variable intensity. Drug induced hypersensitivity reactions are common and potentially alter the therapeutic strategies.
METHOD In a reference population of 1,096 HIV/AIDS patients skin reactions to medication were studied.
RESULTS A total of 149 drug induced reactions were registered in 126 patients (11.5%). A diffuse maculopapular rush was most commonly seen (75.1%). Urticaria (10%), erythema multiforme (2%), Stevens-Johnson (3.3%) and Lyell's syndromes (2.7%) were also observed. Non-nucleoside analogue reverse transcriptase inhibitors (NNRTIs) induced 41 reactions in 327 patients (12.5%). Hypersensitivity to nucleoside analogue reverse transcriptase inhibitors (NRTIs) or protease inhibitors (PIs) was extremely rare.
CONCLUSIONS Severe life-threatening side-effects to HIV medication are not rare and they are associated with drug category.
Key words: Drug eruption, HIV, Lyell's syndrome, NNRTIs, Sulfonamides.
