Last update:
   24-May-2026
 

Arch Hellen Med, 43(Supplement 1), 2026, 70-75

ORIGINAL PAPER

Impact of hemodialysis versus continuous ambulatory peritoneal dialysis on cognitive function in chronic kidney disease

A. Rifai,1 A. Gunawan,1 I.M. Sagala2
1Division of Nephrology and Hypertension, Department of Internal Medicine, Universitas Brawijaya, Malang
2Department of Internal Medicine, Universitas Brawijaya, Malang, Indonesia

OBJECTIVE To compare cognitive impairment in chronic kidney disease (CKD) patients undergoing hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD).

METHOD This cross-sectional study was conducted at Saiful Anwar Hospital, Malang, from August 2024 to January 2025. Data were gathered through a combination of interviews, cognitive evaluations utilizing the Indonesian adaptation of the Montreal Cognitive Assessment (MoCA-INA), and the review of medical records. Statistical analyses included Chi-square, Mann-Whitney tests, and calculation of odds ratios (OR) with 95% confidence intervals (CI).

RESULTS A total of 139 CKD patients participated in this study, divided into HD and CAPD groups. The proportion of cognitive impairment in CAPD (40.0%) was slightly higher than in HD (28.1%), but the difference was not statistically significant (OR: 1.71; 95% CI: 0.82–3.55; p=0.150). The severity of moderate-to-severe cognitive impairment also showed no significant differences. Mean total and cognitive domain scores in CAPD patients were not significantly different compared to HD.

CONCLUSIONS There was no significant difference in the severity of cognitive impairment between CKD patients undergoing HD and CAPD.

Key words: Chronic kidney disease, Cognitive dysfunction, Cross-sectional studies, Hemodialysis, Peritoneal dialysis.

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