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01-Aug-2025
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Arch Hellen Med, 42(5), September-October 2025, 703-706 CASE REPORT Brunner's gland hamartoma after chemotherapy in a patient with diffuse large B-cell lymphoma V. Mitros,1 T. Kanellopoulou,2 F. Kontopidou1 |
Brunner's glands are organs of the exocrine system located in the submucosal layer of the duodenum. We describe a rare case of Brunner's gland hamartoma causing almost total pyloric obstruction. The patient had been diagnosed with diffuse large B-cell lymphoma of the stomach and had been treated successfully with six cycles of immuno-chemotherapy: Rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Six months later, the patient presented with symptoms of gastric obstruction. Upper endoscopy showed a mass that was later resected. The histological analysis was compatible with a Brunner's gland hamartoma. The patient has had a complete recovery. This report underscores the necessity for vigilance for secondary pathologies post-chemotherapy in the gastrointestinal tract, even following complete response of the neoplasm.
Key words: Brunner's gland hamartoma, Chemotherapy, Lymphoma.
