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15-Sep-2021
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Arch Hellen Med, 38(5), September-October 2021, 618-623 ORIGINAL PAPER Racecadotril for treating
acute diarrhea in children F. Farahdina,1 F. Rizaliansyah,2 J.U. Aulya,3 J.K. Fajar4 |
OBJECTIVE To perform a review and meta-analysis concerning the efficacy of racecadotril administration for treating acute diarrhea in children.
METHOD Published papers selected from PubMed, Embase, Cochrane, and Google Scholar were analyzed using a fixed or random-effect model.
RESULTS A total of 11 relevant papers were included in the analysis, which showed that racecadotril administration, compared with control, was associated with reduced duration of diarrhea, with standardized mean difference (SMD): 0.98 (95% CI: 0.55–1.43, p<0.001) and stool volume, SMD: 4.93 (95% CI: 2.98–7.0, p=0.000). Conversely, dehydration (OR: 1.78 [95% CI: 0.70–4.53], p=0.226) and vomiting (OR: 1.44 [95% CI: 0.98–2.12], p=0.066) were not affected significantly by treatment with racecadotril.
CONCLUSIONS Racecadotril administration appears to reduce diarrhea duration and stool volume in children with acute diarrhea.
Key words: Acute diarrhea, Adjuvant therapy, Racecadotril.