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03-Jun-2018
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Arch Hellen Med, 35(3), May-June 2018, 412-415 CASE REPORT Multifocal high-grade gliomas Clinical discussion of synchronous multiple lesions A. Αthanasiou,1,2 A. Prassas,1 G. Alexopoulos,1 K. Tsoleka1 |
Multifocal high-grade gliomas constitute an uncommon clinical entity that poses diagnostic and treatment dilemmas. Here we describe the approach to these central nervous system tumors and the management of a series of four clinical cases. We emphasize the necessity for biopsy soon after symptom onset, to differentiate multifocal gliomas from brain metastases and thus plan individualized treatment. As imaging accuracy increases, so does the reported incidence of diagnosed multifocal lesions. We review the current pathogenetic hypotheses and the clinical characteristics and problems arising from these tumors.
Key words: Anaplastic glioma, Glioblastoma, High-grade glioma, Multifocal glioblastoma, Multifocal glioma.
