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04-Apr-2017
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Arch Hellen Med, 34(2), March-April 2017, 181-190 REVIEW The action of statins through the mevalonate pathway and its impact on the main human systems G. Bazoukis, S. Savvanis, A. Yalouris |
Since their introduction, statins have played a crucial role in the primary and secondary prevention of cardiovascular death. Statins act by blocking the mevalonate pathway, contributing to reduction in cholesterol synthesis. Statins block a number of different branches of the mevalonate pathway leading to the various actions of these drugs, but also to their adverse effects. This is a review of the consequences of mevalonate pathway blocking, with current data on the impact of statins in the various systems of the human body.
Key words: HMG CoA reductase inhibitors, Mevalonate pathway, Statins.
